Pentoxifylline ER is a medication that is used to improve blood flow in the body. It is an extended-release formulation, which means that it slowly releases the medication into the bloodstream over a longer period of time. This medication is commonly prescribed to treat conditions such as peripheral artery disease and intermittent claudication. It works by reducing the viscosity of blood, allowing it to flow more easily through narrowed blood vessels. Pentoxifylline ER may also have anti-inflammatory effects, which can further benefit certain medical conditions.