Aromatase inhibitors are a class of medicines that work by blocking the enzyme aromatase, the enzyme that converts androgens into estrogen. Aromatase inhibitors are used in the treatment of breast cancer to reduce levels of circulating estrogen. This means that less estrogen is available to stimulate the growth of estrogen receptor (ER) positive breast cancer cells, slowing or inhibiting the progression of these cancers. Approximately 80% of all breast cancers are ER positive.
Aromatase inhibitors are unable to prevent the ovaries from making estrogen, which means that they are only used to treat breast cancer in postmenopausal women.
There are three aromatase inhibitors: anastrozole, exemestane, and letrozole.
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Source:drugs.com
Anastrozole
Anastrozole is a medication used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which work by reducing the production of estrogen in the body. This helps to slow down or stop the growth of hormone receptor-positive breast cancer cells. Anastrozole is typically taken orally once a day and is commonly prescribed as part of a comprehensive treatment plan for breast cancer.
Exemestane is a medication used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which work by reducing the production of estrogen in the body. By blocking the conversion of androgens into estrogen, exemestane helps to slow down the growth of hormone receptor-positive breast tumors. It is typically prescribed as a daily oral tablet and is often used as part of a comprehensive treatment plan that may include surgery, radiation therapy, or other medications. Exemestane is only suitable for use in postmenopausal women and should not be used by premenopausal women or men. Common side effects may include hot flashes, joint pain, fatigue, and increased sweating.
Letrozole is a medication commonly used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by reducing the production of estrogen in the body. By inhibiting the enzyme aromatase, letrozole helps to prevent the growth and spread of hormone receptor-positive breast cancer cells. It is typically taken orally once a day and may be prescribed as part of a comprehensive treatment plan that may include surgery, radiation therapy, or other medications. Letrozole is known to have potential side effects, including hot flashes, joint pain, fatigue, and increased risk of osteoporosis. It is important to discuss any concerns or questions about letrozole with a healthcare provider.
